生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 27 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EMCN(51705)
一般描述
The EMCN (endomucin) gene is mapped to human chromosome 4q24. It encodes a 80−120kDa transmembrane sialomucin. Mucin-14 is predominantly expressed in heart, kidney and lungs. Endomucin is a surface glycoprotein localized to the endothelial cells. Mucin-14 is a type 1 integral protein. Endomucin possesses 261 amino acid residues and a serine/threonine-rich extracellular domain. Anti-Mucin-14 Antibody detects endogenous levels of total Mucin-14 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Mucin-14.
Immunogen Range: 201-250
Immunogen Range: 201-250
生化/生理作用
Mucin-14 controls lymphocyte adhesion and its expression is associated with the pathogenesis of rheumatoid arthritis. Mucin-14 associated with O-glycans enables it to promote cell−matrix and cell-cell interactions.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
Park WC, et al.
Scientific reports, 7(1), 17138-17138 (2017)
Alisar Zahr et al.
Nature communications, 7, 10363-10363 (2016-02-03)
Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on quiescent endothelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding
Kazumasa Nishimoto et al.
The Journal of rheumatology, 38(2), 221-228 (2010-12-17)
Endomucin, an endothelial-specific sialomucin, is thought to facilitate "lymphocyte homing" to synovial tissues, resulting in the major histopathologies of rheumatoid arthritis (RA). We examined the association between RA susceptibility and the gene coding endomucin, EMCN. Association studies were conducted with
A Novel Acquired t (2; 4)(q36. 1; q24) with a Concurrent Submicroscopic del (4)(q23q24) in An Adult with Polycythemia Vera
Kjeldsen E
Cancers, 10(7), 214-214 (2018)
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