推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 67 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NFE2L2(4780)
一般描述
Nrf2 （核因子，红细胞2 相关因子2）基因位于人类染色体2q31.2。该编码蛋白位于树突状细胞。它属于转录因子的cap ′n′ collar (CNC) 家族。
抗-NRF2抗体检测内源性总NRF2蛋白水平。
免疫原
抗血清通过靶向来自人Nrf2的合成肽产生。
免疫原范围： 556-605
免疫原范围： 556-605
应用
兔中产生的抗-NRF2，C-末端抗体已被用于蛋白质印迹分析中。
生化/生理作用
Nrf2 （核因子，红细胞2 相关因子2）参与抗氧化和抗炎反应的调节。该编码蛋白是一种转录因子，与靶基因的抗氧化反应元件结合。出于对氧化应激的响应，Nrf2上调与解毒、抗炎、细胞保护和抗氧化通路相关的酶的水平。通过调节磷酸戊糖途径，Nrf2影响癌症细胞中的葡萄糖代谢和ROS（活性氧）稳态。因此，现已确知Nrf2通过促进细胞增殖促使癌症发生。
特点和优势
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
外形
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Daihong Cao et al.
Molecular medicine reports, 25(6) (2022-04-28)
It has been reported that oxidative stress plays a prominent role in diabetic macrovascular diseases. 3,4‑Dihydroxyacetophenone (3,4‑DHAP) has been found to have a variety of biological activities. However, few studies have assessed the antioxidant capacity of 3,4‑DHAP and the underlying
Xin Liu et al.
Biochimica et biophysica acta, 1863(8), 2093-2103 (2016-05-18)
The cap 'n' collar (CNC) family of transcription factors play important roles in resistance of oxidative and electrophilic stresses. Among the CNC family members, NF-E2-related factor 2 (Nrf2) is critical for regulating the antioxidant and phase II enzymes through antioxidant
Yasuko Okano et al.
PloS one, 8(9), e73794-e73794 (2013-09-17)
The transcription factor NRF2 plays a pivotal role in protecting normal cells from external toxic challenges and oxidative stress, whereas it can also endow cancer cells resistance to anticancer drugs. At present little information is available about the genetic polymorphisms
Martin Adam et al.
International journal of cardiology, 228, 341-346 (2016-11-21)
Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a
Lingli Hu et al.
Experimental and therapeutic medicine, 20(1), 283-292 (2020-06-20)
Glucocorticoids (GCs) exert a therapeutic effect in numerous chronic inflammatory diseases. However, chronic obstructive pulmonary disease (COPD) tends to be GC-resistant. Icariin, a major component of flavonoids isolated from Epimedium brevicornum Maxim (Berberidaceae), significantly relieves symptoms in patients with COPD.
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