推荐产品
一般描述
Nuclear factor I A (NF1) belongs to the nuclear factor I family of transcription factors. It exists as four isoforms. The gene encoding NF1 is localized on human chromosome 1p31-p32.
免疫原
The antiserum was produced against synthesized peptide derived from human Nuclear Factor 1.
Immunogen Range: 11-60
Immunogen Range: 11-60
生化/生理作用
Based on the cell type and promoters, nuclear factor I A (NF1) acts either as an activator or repressor. It has an important role in brain development. NF1 acts as a mediator in glial lineage specification and modulates astrocyte terminal differentiation. The protein has been shown to inhibit apoptosis in glioblastoma cells. Mutations in the NF1 gene have been linked to chromosome 1p32-p31 deletion syndrome.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A novel NFIA-NF?B feed-forward loop contributes to glioblastoma cell survival.
Lee J, et al.
Neuro-Oncology, 19(4), 524-534 (2017)
Truncating mutation in NFIA causes brain malformation and urinary tract defects.
Negishi Y, et al.
Human Genome Variation, 2, 15007-15007 (2015)
Loss-of-function variants in NFIA provide further support that NFIA is a critical gene in 1p32-p31 deletion syndrome: A four patient series.
Revah-Politi A, et al.
American Journal of Medical Genetics, 173(12), 3158-3164 (2017)
Linda Marie Starnes et al.
Blood, 114(9), 1753-1763 (2009-06-23)
It is generally conceded that selective combinations of transcription factors determine hematopoietic lineage commitment and differentiation. Here we show that in normal human hematopoiesis the transcription factor nuclear factor I-A (NFI-A) exhibits a marked lineage-specific expression pattern: it is upmodulated
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