SAB4501746
Anti-Galectin 3 antibody produced in rabbit
affinity isolated antibody
别名:
35 kDa lectin, CBP 35, Carbohydrate binding protein 35, GALBP, Galactose-specific lectin 3
产品名称
Anti-Galectin 3 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 26 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LGALS3(3958)
Biochem/physiol Actions
Galectin 3 controls cell activation, migration, adhesion and signaling. It plays a role in cancer progression after it is initiated. Expression of galectin-3 regulates apoptosis and development of T-cell. It participates in several physiological and pathological processes like pre-mRNA splicing, neoplastic transformation and immune responses.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-Galectin 3 Antibody detects endogenous levels of total Galectin 3 protein.
Galectin 3 is a carbohydrate-binding protein. It is abundantly expressed in the extracellular matrix, the cytoplasm and the nucleus. It contains an intrinsically disordered N-terminal domain and a canonical CRD (carbohydrate recognition domain). It is mapped to human chromosome 14q22.
Galectin 3 is a carbohydrate-binding protein. It is abundantly expressed in the extracellular matrix, the cytoplasm and the nucleus. It contains an intrinsically disordered N-terminal domain and a canonical CRD (carbohydrate recognition domain). It is mapped to human chromosome 14q22.
Immunogen
The antiserum was produced against synthesized peptide derived from human Galectin 3.
Immunogen Range: 141-190
Immunogen Range: 141-190
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions.
Lin YH, et al.
The Journal of Biological Chemistry, 292(43), 17845-17856 (2017)
Ping-Ping Lang et al.
Laboratory investigation; a journal of technical methods and pathology, 100(3), 378-386 (2019-09-19)
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has been implicated in the recruitment and adhesion of leukocytes in several cardiac diseases. However, the role of ICAM-1 in
LGALS3 (lectin, galactoside-binding, soluble, 3).
Nangia-Makker P, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(6) (2011)
Expression of galectin-3 modulates T-cell growth and apoptosis.
Yang RY, et al.
Proceedings of the National Academy of Sciences of the USA, 93(13), 6737-6742 (1996)
József Murányi et al.
International journal of molecular sciences, 20(22) (2019-11-14)
Several promising anti-cancer drug-GnRH (gonadotropin-releasing hormone) conjugates have been developed in the last two decades, although none of them have been approved for clinical use yet. Crizotinib is an effective multi-target kinase inhibitor, approved against anaplastic lymphoma kinase (ALK)- or
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