推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 51 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KRT14(3861)
一般描述
抗角蛋白14抗体可检测内源水平的总角蛋白14蛋白。
CK14/KRT14(角蛋白14)是人细胞的细胞角蛋白同种型之一。它是中间丝蛋白,是上皮细胞的特征。它定位于人类染色体17q21。
CK14/KRT14(角蛋白14)是人细胞的细胞角蛋白同种型之一。它是中间丝蛋白,是上皮细胞的特征。它定位于人类染色体17q21。
免疫原
制备用于抗人角蛋白14合成肽的抗血清。
免疫原范围: 1-50
免疫原范围: 1-50
生化/生理作用
CK14/KRT14(角蛋白14)参与涎腺腺样囊性癌(SACC)的集体侵袭。KRT14中的突变导致单纯性大疱性表皮松解。
特点和优势
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。
外形
兔IgG,溶于磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Cancers, 11(9) (2019-08-25)
Epithelial ovarian cancer metastasis is driven by spheroids, which are heterogeneous cancer cell aggregates released from the primary tumour mass that passively disseminate throughout the peritoneal cavity to promote tumour spread, disease recurrence, and acquired chemoresistance. Despite their clinical importance
KRT14 Haploinsufficiency Results in Increased Susceptibility of Keratinocytes to TNF-?-Induced Apoptosis and Causes Naegeli?Franceschetti?Jadassohn Syndrome.
The Journal of Investigative Dermatology, 128(6), 1517-1524 (2008)
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.
PLoS ONE, 12(2), e0171341-e0171341 (2017)
Science advances, 7(5) (2021-01-31)
Glucocorticoids (GC), synthesized by the 11β-hydroxylase (Cyp11b1), control excessive inflammation through immunosuppressive actions. The skin was proposed to regulate homeostasis by autonomous GC production in keratinocytes. However, their immunosuppressive capacity and clinical relevance remain unexplored. Here, we demonstrate the potential
The EMBO journal, 39(24), e103303-e103303 (2020-11-21)
HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), is a critical regulator of inflammation. However, how HOIP itself is regulated to control inflammatory responses is unclear. Here, we discover that site-specific ubiquitination of K784 within human
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