产品名称
Anti-JAK2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 130 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JAK2(3717)
Biochem/physiol Actions
JAK2 (janus kinase 2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-JAK2 Antibody detects endogenous levels of total JAK2 protein.
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the Jak family of proteins. The JAK2 gene is located on human chromosome 9p24.
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the Jak family of proteins. The JAK2 gene is located on human chromosome 9p24.
Immunogen
The antiserum was produced against synthesized peptide derived from human JAK2.
Immunogen Range: 906-955
Immunogen Range: 906-955
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
Stefan J, et al.
Cancer Genetics, 103(4), 489-495 (2002)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
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