生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 87 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ITGB3(3690)
一般描述
Anti-Integrin β3 Antibody detects endogenous levels of total Integrin β3 protein.
ITGB3 (integrin subunit β 3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.
免疫原
The antiserum was produced against synthesized peptide derived from human Integrin beta3.
Immunogen Range: 739-788
Immunogen Range: 739-788
生化/生理作用
Mutations in ITGB3 (integrin subunit β 3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells promoted by reactive oxygen species.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells
Lei Y, et al.
Molecular and Cellular Proteomics, 10(10) (2011)
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models
Nurden AT, et al.
Blood, 118(23), 5996-6005 (2011)
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Ghevaert C, et al.
Blood, 111(7), 3407-3414 (2008)
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