推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 61 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HSPD1(3329)
一般描述
Anti-HSP60 antibody detects endogenous levels of total HSP60 protein.
Hsp60 (heat shock protein family D member 1) is a mitochondrial chaperone, located in the endoplasmic reticulum (ER). It is mapped to human chromosome 2q33.1.
免疫原
The antiserum was produced against synthesized peptide derived from human HSP60.
Immunogen Range: 511-560
Immunogen Range: 511-560
应用
Anti-HSP60, C-Terminal antibody has been used in SDS/PAGE and western blot analysis.
生化/生理作用
Hsp60 (heat shock protein family D member 1) helps to gather proteins that are imported into mitochondrial matrix. Overexpression of Hsp60 results in Behcet′s Disease (BD),Crohn′s disease, juvenile dermatomyositis (JDM), and juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis
Arya RK, et al.
Scientific Reports (2015)
OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation
Barrera M, et al.
Febs Letters, 590(19), 3309-3322 (2016)
Miguel Barrera et al.
FEBS letters, 590(19), 3309-3322 (2016-09-03)
Remodeling of crista junctions (CJs) is observed in numerous human disorders and during apoptosis. The functional interplay of OPA1 and MIC60, two key players in this context, is unclear. We show that OPA1 modulates cristae morphology but is dispensable for
HSP60: a double edge sword in autoimmunity
Landstein D, et al.
Oncotarget, 6(32), 32299-32300 (2015)
HSPD1 (heat shock 60kDa protein 1)
Faried A and Faried L S
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
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