生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 311 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... APC(324)
一般描述
Adenomatous polyposis coli (APC) is a tumour suppressor gene. It is located on human chromosome 5q21.
Anti-APC Antibody detects endogenous levels of total APC protein.
免疫原
The antiserum was produced against synthesized peptide derived from human APC.
Immunogen Range: 2794-2843
Immunogen Range: 2794-2843
生化/生理作用
Adenomatous polyposis coli (APC) plays an important role in cell division, adhesion and migration. Mutations in APC gene is associated with colorectal carcinomas.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer
Tekcham DS, et al.
The Indian Journal of Medical Research, 143(Suppl 1) (2016)
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through ?-catenin pathway in colorectal cancer.
Li Y
Oncogene, 35(35), 4558-4568 (2016)
Lorenzo Alibardi
Journal of morphology, 283(5), 677-688 (2022-02-24)
Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is the "adenomatous polyposis coli (apc)"
Hongfei Ge et al.
Molecular neurobiology (2021-10-13)
Spinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI.
Till Ringel et al.
Cell stem cell, 26(3), 431-440 (2020-03-07)
Forward genetic screens with genome-wide CRISPR libraries are powerful tools for resolving cellular circuits and signaling pathways. Applying this technology to organoids, however, has been hampered by technical limitations. Here we report improved accuracy and robustness for pooled-library CRISPR screens by
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