生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 24 kDa
种属反应性
rat, human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HMGB1(3146)
一般描述
Anti-HMGB1 Antibody detects endogenous levels of total HMGB1 protein.
High mobility group box 1 (HMGB1) is a nuclear protein that belongs to the damage-associated molecular pattern (DAMP) family. It is located on human chromosome 13q12.
免疫原
The antiserum was produced against synthesized peptide derived from human HMGB1.
Immunogen Range: 131-180
Immunogen Range: 131-180
生化/生理作用
High mobility group box 1 (HMGB1) is involved in bone remodeling and ectopic calcification pathogenesis. It initiates neuroinflammation after epileptogenic injuries. HMGB1 also binds to chromatin and modulates gene transcription.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Roles of High Mobility Group Box 1 in Cardiovascular Calcification.
Chen Q, et al.
Cellular Physiology and Biochemistry, 42(2), 427-440 (2017)
A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation.
Mandrile G,et al.
Case Reports in Genetics (2014)
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.
Walker LE, et al.
The Journal of Clinical Investigation, 127(6), 2118-2132 (2017)
Laura Patricia Whittall-Garcia et al.
Lupus science & medicine, 11(1) (2024-01-05)
To determine if the serum levels of neutrophil extracellular trap (NET) remnants (Elastase-DNA and HMGB1-DNA complexes) at the time of a lupus nephritis (LN) flare predict renal outcomes in the following 24 months. This was a retrospective study performed in
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