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主要文件

安全信息

SAB4501295

Sigma-Aldrich

Anti-GLUR2 antibody produced in rabbit

affinity isolated antibody

别名:

GluR-2, GluR-B, GluR-K2, Glutamate receptor 2, Glutamate receptor ionotropic

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 98 kDa

种属反应性

human, mouse, rat

浓度

~1 mg/mL

技术

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... GRIA2(2891)

一般描述

Anti-GLUR2 Antibody detects endogenous levels of total GLUR2 protein.
GLUR2 (glutamate receptor 2) is coded by gria2 gene. It is mapped to human chromosome 4q32. It is abundantly expressed in the brain.

免疫原

The antiserum was produced against synthesized peptide derived from human GluR2.

Immunogen Range: 834-883

应用

Anti-GLUR2, C-Terminal antibody has been used in electron microscopy.

生化/生理作用

Presence of the glutamate receptor 2 (GluR2) subunit prevents calcium influx through AMPA-receptor complexes. Deletion of this subunit results in enhanced hippocampal long-term potentiation. As such, AMPA receptors play crucial roles in normal neuronal activity, including synaptic plasticity, synaptic scaling, homeostatic synaptic plasticity, learning and memory, as well as in synaptogenesis and the formation of neuronal circuitry.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2)
Priya A, et al.
Biochimica et Biophysica Acta (2014)
A nomenclature for ligand-gated ion channels
Collingridge GL, et al.
Neuropharmacology, 56 (2009)
Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
Mead AN and Stephens DN
The Journal of Neuroscience, 23 (2003)
Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure
Hausknecht K, et al.
Neuropsychopharmacology, 40 (2015)
Hu Peng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(38) (2024-08-16)
Ribbon synapses of inner hair cells (IHCs) are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles (SVs), however, remains elusive. This study showed that hair cell

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