生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 30 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ATF5(22809)
一般描述
Activating transcription factor 5 (ATF5) belongs to the ATF/cAMP response element-binding protein family. It is an anti-apoptotic protein that has 282 amino acids and is located on human chromosome 19q13. It is expressed in various cancers like prostate, rectal, colon, endometrium, breast, ovary, pancreas, gastric etc.
Anti-ATF5 Antibody detects endogenous levels of total ATF5 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human ATF5.
Immunogen Range: 221-270
Immunogen Range: 221-270
生化/生理作用
Activating transcription factor 5 (ATF5) participates in metabolite homeostasis, cellular proliferation, differentiation, apoptosis and regulation of the cell cycle. It controls neural progenitor cell and adipose-derived stem cell differentiation.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Ishihara S, et al.
Oncotarget, 6, 4602-4614 (2015)
DNA methylation level of promoter region of activating transcription factor 5 in glioma
Hua XM, et al.
Journal of Zhejiang University. Science. B, 16, 757-762 (2015)
ATF5 (activating transcription factor 5)
Ching A KK and Wong N
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Role of ATF5 in the invasive potential of diverse human cancer cell lines
Nukuda A, et al.
Biochemical and Biophysical Research Communications, 474, 509-514 (2016)
Kari A Gaither et al.
PloS one, 15(6), e0225044-e0225044 (2020-07-01)
Cellular stress response mechanisms normally function to enhance survival and allow for cells to return to homeostasis following an adverse event. Cancer cells often co-opt these same mechanisms as a means to evade apoptosis and mitigate a state of constant
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