生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 237 kDa
种属反应性
mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PIKFYVE(200576)
一般描述
PIKFYVE belongs to an evolutionarily ancient gene family of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)enzymes. PIKFYVE gene is located on human chromosome 2q34. Anti-PIP5K antibody detects endogenous levels of total PIP5K protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PIP5K.
Immunogen Range: 71-120
Immunogen Range: 71-120
生化/生理作用
Phosphatidylinositol 4-phosphate 5-kinase (PIP5K)/Phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE) protein plays a key role in phosphoinositide 5-kinase and protein kinase activity. It is essential for post-Golgi vesicle processing. Mutation in the PIKFYVE gene is associated with fleck corneal dystrophy (FCD).
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Alicia Cabezas et al.
Gene, 371(1), 34-41 (2006-02-02)
Yeast Fab1 is a phosphatidylinositol 3-phosphate 5-kinase involved in endocytic membrane traffic and vacuole homeostasis. Here we have cloned and sequenced the cDNA for the human homologue of Fab1, PIKfyve. The cDNA has an open reading frame of 6294 bp
Jessica A Gee et al.
Molecular vision, 21, 1093-1100 (2015-09-24)
To report the identification of a novel frameshift mutation and copy number variation (CNV) in PIKFYVE in two probands with fleck corneal dystrophy (FCD). Slit-lamp examination was performed to identify characteristic features of FCD. After genomic DNA was collected, PCR
Andreas Kotoulas et al.
Molecular vision, 17, 2776-2781 (2011-11-09)
To report the findings of the clinical and molecular evaluation in a Greek family with fleck corneal dystrophy (CFD). A 58-year-old woman was seen on routine ophthalmic examination and diagnosed as having CFD. All available family members were examined to
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