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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 23 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... APOBEC3A(200315)
一般描述
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) belongs to the AID/APOBEC family of enzymes. It is located on human chromosome 22q13.1.
Anti-APOBEC3A antibody detects endogenous levels of total APOBEC3A protein.
免疫原
The antiserum was produced against synthesized peptide derived from human APOBEC3A.
Immunogen Range: 27-76
Immunogen Range: 27-76
应用
Anti-APOBEC3A antibody has been used in western blotting.
生化/生理作用
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) deaminates methylated cytosine bases in DNA. It is considered as a viral DNA mutator and performs broad antiviral activity.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G
Yang Y, et al.
The Journal of Investigative Dermatology, 137(4), 810-818 (2017)
Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
Aynaud MM, et al.
The Journal of Biological Chemistry (2012)
Jan-Hendrik Bockmann et al.
The Journal of infectious diseases, 220(4), 567-577 (2019-03-30)
Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate cytosine deamination and subsequent purging of nuclear hepatitis B virus (HBV) DNA, we investigated whether IFN-β
APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA
Schutsky EK, et al.
Nucleic Acids Research, 45(13), 7655-7665 (2017)
Rodolphe Suspène et al.
Nucleic acids research, 45(6), 3231-3241 (2017-01-20)
Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidine deaminases can initiate catabolism of
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