生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 23 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EFNA1(1942)
一般描述
EphrinA1 (EFNA1), also known as angiogenesis factor, is encoded by the gene mapped to human chromosome 1q21-22. The encoded protein belongs to subclass A of ephrin family. EFNA1 is localized to cell membrane via a glycosylphosphatidylinositol (GPI) moiety. EFNA1 ligand preferentially binds to the receptor tyrosine kinase, Eph receptor 2 (EphA2).
免疫原
The antiserum was produced against synthesized peptide derived from human EFNA1.
Immunogen Range: 66-115
Immunogen Range: 66-115
应用
Anti-EFNA1 antibody produced in rabbit has been used in western blot analysis.
生化/生理作用
EphrinA1 (EFNA1) and its primary receptor, Eph receptor 2 (EphA2) are associated with various cancers, such as urinary bladder carcinoma, breast cancer gastric cancer, glioma and malignant mesothelioma. Expression pattern of EFNA1 can be used as a potential prognostic marker in colorectal cancer (CRC) patients and other human malignancies. Experimental studies state that, EphrinA1 (EFNA1) can be involved in both tumor promotion and inhibition, based on whether ephrin-A1 is bound to the receptor in soluble or membrane bound form, respectively. Activation of EphA2, induces indirect growth signal by overcoming ‘contact inhibition′.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3.
Cerretti DP, et al.
Genomics, 33(2), 277-282 (1996)
Lyka Potla et al.
Cancer letters, 175(2), 187-195 (2001-12-14)
Ephrin A1 (EFNA1) is a GPI-anchored ligand that preferentially binds to the receptor tyrosine kinase, EphA2. EphA2 is over-expressed in malignant melanocytes and in prostate carcinoma cells. Whether activation of EphA2 by EFNA1 is involved in aberrant growth or differentiation
Hirofumi Yamamoto et al.
International journal of oncology, 42(2), 549-555 (2012-12-22)
We previously studied hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC) and determined several potential prognostic factors, including expression
T Tawadros et al.
British journal of cancer, 107(10), 1737-1744 (2012-10-06)
High intake of omega-6 polyunsaturated fatty acids (PUFA) has been associated with clinical progression in prostate cancer (CaP). This study investigates the signalling mechanism by which the omega-6 PUFA arachidonic acid (AA) induces prostatic cellular migration to bone marrow stroma.
Sho Kohara et al.
Biomedicines, 10(12) (2022-12-24)
Kupffer cells are maintained via self-renewal in specific microenvironmental niches, primarily the liver sinusoidal endothelial cells (LSECs). In this study, we propagated tissue-resident macrophages (Mø) from mouse liver using mixed culture with hepatic fibroblastic cells. Propagated liver Mø express Id3
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