产品名称
抗-蛋白聚糖(裂解-Asp369),N-端 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 44 kDa
species reactivity
human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Asp369)
Quality Level
Gene Information
human ... ACAN(176)
Application
N端抗聚集蛋白聚糖(裂解的Asp369)抗体已用于蛋白质印迹和免疫染色。
Biochem/physiol Actions
聚集蛋白聚糖的突变会导致常染色体显性遗传的矮小身材,并加速骨骼成熟。聚集蛋白聚糖基因(AGC1)的可变重复区域中的突变导致脊椎骨发育异常。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。
General description
抗-聚集蛋白聚糖(裂解-Val369)抗体可检测激活聚集蛋白聚糖(裂解-Val369)蛋白片段的内源性水平。
聚集蛋白聚糖是人软骨的大聚集硫酸软骨素蛋白聚糖。它由AGC1(聚集蛋白聚糖)基因编码。它定位于人类染色体15q26.1。
Immunogen
该抗血清是针对衍生自人聚集蛋白聚糖的合成肽而生成的。
免疫原范围: 320-369
免疫原范围: 320-369
Physical form
兔IgG,溶于磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。
未找到合适的产品?
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations.
Gkourogianni A, et al.
The Journal of Clinical Endocrinology and Metabolism, 102(2), 460-469 (2017)
Gene expression profiles of early chondrogenic markers in dedifferentiated fat cells stimulated by bone morphogenetic protein 4 under monolayer and spheroid culture conditions in vitro
Eiko A, et al.
Orthodontic Waves, 75(4), 97-104 (2016)
Qiang Zhang et al.
Journal of cellular biochemistry, 120(3), 3401-3414 (2018-10-29)
Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation
A Mutation in the Variable Repeat Region of the Aggrecan Gene (AGC1) Causes a Form of Spondyloepiphyseal Dysplasia Associated with Severe, Premature Osteoarthritis
Lindsay G, et al.
American Journal of Human Genetics, 77(3), 484-490 (2005)
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege K J, et al.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持