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Merck
CN

SAB4500662

抗-蛋白聚糖(裂解-Asp369),N-端 兔抗

affinity isolated antibody

别名:

CSPCP, CSPG1, 硫酸软骨素蛋白聚糖核心蛋白1, 蛋白聚糖核心蛋白, 软骨特异性蛋白聚糖核心蛋白

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
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产品名称

抗-蛋白聚糖(裂解-Asp369),N-端 兔抗, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

proteolytically cleaved (Asp369)

Quality Level

Gene Information

human ... ACAN(176)

Application

N端抗聚集蛋白聚糖(裂解的Asp369)抗体已用于蛋白质印迹和免疫染色。

Biochem/physiol Actions

聚集蛋白聚糖的突变会导致常染色体显性遗传的矮小身材,并加速骨骼成熟。聚集蛋白聚糖基因(AGC1)的可变重复区域中的突变导致脊椎骨发育异常。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

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General description

抗-聚集蛋白聚糖(裂解-Val369)抗体可检测激活聚集蛋白聚糖(裂解-Val369)蛋白片段的内源性水平。
聚集蛋白聚糖是人软骨的大聚集硫酸软骨素蛋白聚糖。它由AGC1(聚集蛋白聚糖)基因编码。它定位于人类染色体15q26.1。

Immunogen

该抗血清是针对衍生自人聚集蛋白聚糖的合成肽而生成的。

免疫原范围: 320-369

Physical form

兔IgG,溶于磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

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Lot/Batch Number

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A Mutation in the Variable Repeat Region of the Aggrecan Gene (AGC1) Causes a Form of Spondyloepiphyseal Dysplasia Associated with Severe, Premature Osteoarthritis
Lindsay G, et al.
American Journal of Human Genetics, 77(3), 484-490 (2005)
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege K J, et al.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)

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