推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 19 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COX4I1(1327)
一般描述
Anti-COX41 Antibody detects endogenous levels of total COX41 protein.
COX41 (cytochrome c oxidase subunit 4I1) is located on human chromosome 16q24. COX4NB (COX4 neighbour) and COX4I1 (COX4 isoform 1) belongs to the cytochrome C oxidase subunit IV (COX4) family.
免疫原
The antiserum was produced against synthesized peptide derived from human COX41.
Immunogen Range: 11-60
Immunogen Range: 11-60
生化/生理作用
COX4 isoform 1 (COX4-1) (COX4-1) may play an important role in glioma chemoresistance. It regulates the upregulation of BMI1 (polycomb complex protein BMI1). It is necessary for the multiplication of GBM (glioblastoma multiforme). In cells, expression of COX4-1 is necessary to maintain the stability of mitochondria and ROS (reactive oxygen species) homeostasis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A small de novo 16q24.1 duplication in a woman with severe clinical features
Quemener-Redon S, et al.
European Journal of Medical Genetics, 56(4), 211-215 (2013)
Fan Yang et al.
Journal of cellular biochemistry, 119(2), 2427-2439 (2017-09-16)
Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated
Claudia R Oliva et al.
Oncotarget, 6(6), 4330-4344 (2015-03-03)
Nuclear-encoded cytochrome c oxidase subunit 4 (COX4) is a key regulatory subunit of mammalian cytochrome c oxidase, and recent studies have demonstrated that COX4 isoform 1 (COX4-1) could have a role in glioma chemoresistance. The Polycomb complex protein BMI1 is
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