生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 18 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CFL2(1073)
一般描述
Anti-Cofilin Antibody detects endogenous levels of total Cofilin protein.
Cofilin is a member of the actin depolymerizing factor/cofilin family. Among all members, cofilin‐1 is the predominant isoform. It is located on human chromosome 11q13.
免疫原
The antiserum was produced against synthesized peptide derived from human Cofilin.
Immunogen Range: 61-110
Immunogen Range: 61-110
应用
Anti-Cofilin antibody has been used in western blotting.
生化/生理作用
Cofilin plays an important role in actin filament remodeling that is required in chemotaxis, cell migration and invasion of tumor cells.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14
Gillett GT, et al.
Annals of Human Genetics, 60 (1996)
Jun-Bum Park et al.
Oncotarget, 5(19), 9382-9395 (2014-09-23)
Malignant gliomas are highly proliferative and invasive neoplasms where total surgical resection is often impossible and effective local radiation therapy difficult. Consequently, there is a need to develop a greater understanding of the molecular events driving invasion and to identify
Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer
Satoh M, et al.
Cancer Science, 108, 795-803 (2017)
Irena Audzeyenka et al.
Journal of cellular physiology, 236(6), 4655-4668 (2020-11-28)
Insulin plays a major role in regulating glucose homeostasis in podocytes. Protein kinase G type Iα (PKGIα) plays an important role in regulating glucose uptake in these cells. Rac1 signaling plays an essential role in the reorganization of the actin
Irena Audzeyenka et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118723-118723 (2020-04-18)
A growing body of evidence suggests a role of proteolytic enzymes in the development of diabetic nephropathy. Cathepsin C (CatC) is a well-known regulator of inflammatory responses, but its involvement in podocyte and renal injury remains obscure. We used Zucker
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