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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 56 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TXNRD2(10587)
一般描述
Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein.
Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR).
免疫原
The antiserum was produced against synthesized peptide derived from human TRXR2.
Immunogen Range: 471-520
Immunogen Range: 471-520
生化/生理作用
Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mitochondrial thioredoxin system effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis.
The Journal of Biological Chemistry, 279(26), 27302-27314 (2004)
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Diabetes Research and Clinical Practice, 108(2), 323-328 (2015)
The Genes Associated with RNA Editing and Glioma on the Chromosome 22q.
Advances in Medical Sciences, 2(1) (2014)
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation
Biochemical and Biophysical Research Communications, 304(1), 119-124 (2003)
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