SAB4500130
Anti-Centromeric Protein A antibody produced in rabbit
affinity isolated antibody
别名:
CENA, CENP-A, CENPA, Centromere autoantigen A, Centromere protein A
产品名称
Anti-Centromeric Protein A antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 15 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CENPA(1058)
Biochem/physiol Actions
Centromeric Protein A (CENPA) plays a vital role in centromere specification and facilitates its mitotic function and epigenetic maintenance. CENP-A-nucleosome associated complex (NAC) is implicated in the regulation of chromosome congression and spindle bipolarity. Disorganization of this complex leads to change in chromosome alignment and segregation that prevent cell survival regardless of continued centromere-derived mitotic checkpoint signaling.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-Centromeric protein A Antibody detects endogenous levels of total Centromeric protein A protein.
Centromeric Protein A (CENPA), is encoded by the gene mapped to human chromosome 2p23.3. The encoded protein is a longer variant of histone H3 in humans.
Immunogen
The antiserum was produced against synthesized peptide derived from human Centromeric Protein A.
Immunogen Range: 1-50
Immunogen Range: 1-50
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The CENP?A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
McClelland S E, et al.
The Embo Journal, 26(24), 5033-5047 (2007)
CENP-A modifications on Ser68 and Lys124 are dispensable for establishment, maintenance, and long-term function of human centromeres
Fachinetti D, et al.
Developmental Cell, 40(1), 104-113 (2017)
The human CENP-A centromeric nucleosome-associated complex
Foltz D R, et al.
Nature Cell Biology, 8(5), 458-458 (2006)
A dual inhibitory mechanism sufficient to maintain cell cycle restricted CENP-A assembly
Stankovic A, et al.
Molecular Cell, 65(2), 231-246 (2017)
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Sadakierska-Chudy A
Neurotoxicity Research, 27(1), 84-97 (2015)
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