推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 80 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADARB1(104)
一般描述
Adenosine deaminase, RNA specific B1 (ADARB1) is encoded by the gene mapped to human chromosome 21q22.3, a region associated with familial bipolar disorder. ADARB1 is characterized with two double-stranded RNA-binding domains and a deaminase domain involved in editing action.
免疫原
The antiserum was produced against synthesized peptide derived from human ADARB1.
Immunogen Range: 481-530
Immunogen Range: 481-530
生化/生理作用
Adenosine deaminase, RNA specific B1 (ADARB1) enzyme plays a vital role in editing pre-mRNA of glutamate receptor B subunit. Combined effect of ADARB1 and HTR2C (5-Hydroxytryptamine Receptor 2C) variants contribute to the suicide attempt (SA) vulnerability in psychiatric patients. ADARB1 is a candidate gene for neurological diseases, such as bipolar affective disorder and epilepsy. Decrease in the activity of ADAR2 enzyme results in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated death of motor neurons in mice. ADARB1 enzyme is expressed consistently in carcinomas and sarcomas, and it is upregulated in lymphomas and seminomas when compared to normal tissues.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.
Hideyama T, et al.
The Journal of Neuroscience, 30(36), 11917-11925 (2010)
Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders.
Karanovic J, et al.
The World Journal of Biological Psychiatry : The Official Journal of the World Federation of Societies of Biological Psychiatry, 16(4), 261-271 (2015)
Sequence analysis of ADARB1 gene in patients with familial bipolar disorder.
Amore M, et al.
Journal of Affective Disorders, 81(1), 79-85 (2004)
Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.
Flanagan JM, et al.
Molecular Cancer Therapeutics, 8(1), 249-260 (2009)
L Mittaz et al.
Genomics, 41(2), 210-217 (1997-04-15)
RED1 is a double-stranded RNA-specific editase characterized in the rat and is implicated in the editing of glutamate receptor subunit pre-mRNAs, particularly in the brain. Starting from human ESTs homologous to the rat RED1 sequence, we have characterized two forms
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