推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous glycerol solution
种属反应性
human, mouse
技术
immunohistochemistry: 1: 20-100
western blot: 1:200-1:1000
登记号
NP_054862
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CD274(29126)
一般描述
程序性细胞死亡1配体1（PD-L1），又称分化簇（CD274）或B7同源物1（B7-H1），是不断增长的B7免疫分子家族的成员。PD-L1是一种细胞表面免疫球蛋白，胞外区有两个Ig样结构域和一个短胞质结构域。该蛋白在心脏、骨骼肌、胎盘和肺中高表达，在胸腺、脾脏、肾脏和肝脏中弱表达。PD-L1在活化的T细胞、B细胞、树突状细胞、角质形成细胞和单核细胞上表达。编码它的基因位于人类染色体9p24.1。
免疫原
人 CD274 的合成肽
生化/生理作用
程序性细胞死亡1配体1（PD-L1）参与细胞和体液免疫反应的调节。（4）脂多糖 (LPS) 和干扰素-γ（IFNG）激活后，PD-L1在T细胞和B细胞、树突状细胞、角质形成细胞和单核细胞中上调，并在表面Ig交联激活的B细胞中上调。PD-L1以白细胞介素-2依赖性方式和程序性细胞死亡1（PDCD1）非依赖性方式参与共刺激信号，该信号对T细胞增殖以及白细胞介素-10（IL10）和IFNG的产生至关重要。
特点和优势
完全放心地试用我们的抗体。如果抗体在您的应用中不起作用，我们将提供全额信用或替代抗体。了解更多。
外形
兔 IgG，溶于 pH7.4 PBS，0.05％ NaN3，40％ 甘油。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Ragnar O Vilmundarson et al.
Frontiers in immunology, 13, 868053-868053 (2022-07-23)
Interferon regulatory factor 2 binding protein 2 (Irf2bp2), a co-repressor of Irf2, is required for fetal hepatic erythropoiesis through the expansion of erythromyeloid progenitors. Mice with germline ablation of the entire Irf2bp2 transcript produced no viable Irf2bp2-null pups in first
Mengdi He et al.
Journal of gynecologic oncology, 32(3), e32-e32 (2021-04-08)
To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker. We employed CIBERSORT and xCell method to evaluate the abundances of 23 cells types in tumor microenvironment. Five
The role of B7 family molecules in hematologic malignancy.
Greaves P and Gribben JG
Blood, 121(5), 734-744 (2013)
Xing Huang et al.
Cancer immunology research, 7(10), 1580-1590 (2019-08-11)
PD-1 (CD279)-PD-L1 (CD274) inhibitory signaling is critical for cancer immune evasion, and thus has become one of the major targets in anticancer immunotherapy. There are several studies that demonstrate the potent effects of posttranslational modifications of CD274 on immune inactivation
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Green MR
Blood, 116(17), 3268-3277 (2010)
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