推荐产品
产品名称
Anti-CSPG4, affinity isolated antibody
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
human, mouse, rat
技术
immunohistochemistry: 1:20-1:100
western blot: 1:500-1:2000
登记号
NP_001888
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CSPG4(1464)
一般描述
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
免疫原
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
生化/生理作用
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Svendsen A, et al.
Acta Neuropathologica, 122(4), 495-510 (2011)
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C, et al.
Molecular Oncology, 1(4), 425-430 (2008)
Functional roles of CSPG4/NG2 in chondrosarcoma
Jamil NS, et al.
International Journal of Experimental Pathology, 97(2), 178-186 (2016)
A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
Staub E, et al.
Febs Letters, 527(1-3), 114-118 (2002)
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
Wang J, et al.
PLoS ONE, 6(7), e23062-e23062 (2011)
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