推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
human, mouse
技术
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:2000
登记号
NP_002174
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IL3RA(3563)
一般描述
Interleukin 3 receptor subunit α alpha (IL3RA or CD123) gene is localized in the X and Y chromosomes. It comprises a highly mobile N-terminal domain (NTD) region and fibronectin type III (FnIII) domain. CD123 is expressed on early hematopoietic cells and is a type I cytokine receptor.
免疫原
Synthetic peptide of human interleukin 3 receptor, alpha (low affinity)
生化/生理作用
Elevated expression of IL3RA is reported in chronic myeloid leukemia (CML).) It may serve as a therapeutic potential to treat acute myelogenous leukemia (AML).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
M Joseph et al.
Journal of medical genetics, 33(11), 906-911 (1996-11-01)
Colony stimulating factor-2 receptor alpha (CSF2RA) and interleukin-3 receptor alpha (IL3RA), two genes from the chromosome Xp and Yp pseudoautosomal region (PAR), have been suggested as candidate genes for short stature in Turner syndrome. We report three girls with X;Y
Prognostic relevance of CD123 expression in adult AML with normal karyotype.
Gina Jiang et al.
British journal of haematology, 188(1), 181-184 (2019-11-24)
C T Jordan et al.
Leukemia, 14(10), 1777-1784 (2000-10-06)
Recent studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). LSCs have been documented for nearly all AML subtypes and have been phenotypically described
Sophie E Broughton et al.
Nature communications, 9(1), 386-386 (2018-01-28)
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits
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