生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
55 kDa
种属反应性
rat, mouse, human
浓度
2.8 mg/mL
技术
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
同位素/亚型
IgG
登记号
NP_036211.2
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... DGAT1(8694)
一般描述
Diacylglycerol-acyltransferase 1 (DGAT1), a transmembrane protein, is a member of the membrane-bound O-acyltransferase superfamily. It is seen in the endoplasmic reticulum of several cells. DGAT1 is ubiquitously expressed in humans. A high level of mRNA is seen in the small intestine. It has three transmembrane domains. The DGAT1 gene is mapped to human chromosome 8q24.3.
特异性
The antibody detects endogenous levels of total DGAT1 protein.
免疫原
Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1
应用
Anti-DGAT1 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Diacylglycerol-acyltransferase 1 (DGAT1) converts diacylglycerol and fatty acyl-CoA to triacylglycerol. It participates in energy storage. DGAT1 plays a key role in cancer progression. Activity of DGAT1 is essential for the physiologic absorption of vitamin D. Absence of DGAT1 activity is linked with body weight and adiposity reduction, and increased insulin sensitivity. Aberrations in the DGAT1 gene are associated with congenital diarrheal disorder (CDD).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Aditi Gupta et al.
European journal of medical genetics, 63(4), 103817-103817 (2019-11-30)
DGAT1, a gene encoding a protein involved in lipid metabolism, has been recently implicated in causing a rare nutritional and digestive disease presenting as Congenital Diarrheal Disorder (CDD). Genetic causes of malnutrition can be classified as metabolic disorders, caused by
A Mercadé et al.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 122(3), 161-164 (2005-09-01)
DGAT1 is a microsomal enzyme that catalyses the final step in triglycerides synthesis. DGAT1-deficient mice are viable, lean, fertile and resistant to diet induced obesity. We have previously identified a quantitative trait loci (QTL) on chromosome 4 that affects fatty
Ping He et al.
BMC cancer, 21(1), 252-252 (2021-03-23)
Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissue indicated a poor outcome in cancer patients. However, the
Chunyan Feng et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(8), 834-843 (2018-04-21)
Levels of polyunsaturated phosphatidylcholine (PC) influence plasma membrane structure and function. Phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation/reacylation remodeling via Lands' cycle (non-Kennedy pathway). The reacylation is catalyzed by lysophosphatidylcholine acyltransferase (LPCAT)
Justin Chun et al.
Journal of the American Society of Nephrology : JASN, 33(5), 889-907 (2022-03-03)
Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry are major contributors to the large racial disparity in rates of human kidney disease. We previously demonstrated that recruitment of APOL1 risk variants G1
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