一般描述
Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.
特异性
The antibody detects endogenous levels of total UCN protein.
免疫原
Synthetic peptide corresponding to residues near the C terminal of human urocortin
应用
Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.
生化/生理作用
Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.
特点和优势
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外形
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob GF and Heinrichs SC
Brain Research, 848(1-2), 141-152 (1999)
Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
Singh LK, et al.
Journal of Pharmacology and Experimental Therapeutics, 288(3), 1349-1356 (1999)
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway
Schulman D, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 52(4), H1481-H1488 (2002)
W J Giardino et al.
Translational psychiatry, 7(1), e1021-e1021 (2017-02-01)
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a
Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system
Giardino WJ, et al.
Translational Psychiatry, 7(1), e1021-e1021 (2017)
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