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安全信息

SAB4300738

Sigma-Aldrich

Anti-Collagen IV antibody produced in rabbit

affinity isolated antibody

别名:

ALPHA-1 CHAIN ARRESTEN, COL4A1 NC1 domain, COLLAGEN OF BASEMENT MEMBRANE, alpha 1 type IV collagen preproprotein, collagen IV alpha-1 polypeptide

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

160 kDa

种属反应性

mouse, human

浓度

1.0 mg/mL

技术

immunohistochemistry: 1:50-1:100
western blot: 1:500-1:3000 (Cell Lysate)

同位素/亚型

IgG

登记号

NP_001836.2

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... COL4A1(1282)

相关类别

一般描述

COL4A1 (collagen type IV α 1 chain) belongs to the collagen family. It has an N-terminal 7S domain, a C-terminal globular domain (NC1), and the central triple helical part with short interruptions of the Gly-X-Y repeats. It is an important constituent of type IV collagen in the basement membrane. The COL4A1 gene is located on human chromosome 13q34.

特异性

The antibody detects endogenous levels of total Collagen IV protein.

免疫原

Synthesized peptide derived from human Collagen IV.

应用

Collagen Type IV from human cell culture has been used in immunofluorescent analysis.

生化/生理作用

COL4A1 (collagen type IV α 1 chain) related disorder is associated with pulmonary complication. Mutations in COL4A1 result in familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD) and hemorrhagic stroke.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Sakurai Y, et al.
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A severe pulmonary complication in a patient with COL4A1-related disorder: A case report.
Abe Y, et al.
European Journal of Medical Genetics, 60(3), 169-171 (2017)
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