SAB4300738
Anti-Collagen IV antibody produced in rabbit
affinity isolated antibody
别名:
ALPHA-1 CHAIN ARRESTEN, COL4A1 NC1 domain, COLLAGEN OF BASEMENT MEMBRANE, alpha 1 type IV collagen preproprotein, collagen IV alpha-1 polypeptide
产品名称
Anti-Collagen IV antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
160 kDa
species reactivity
mouse, human
concentration
1.0 mg/mL
technique(s)
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:3000 (Cell Lysate)
isotype
IgG
accession no.
NP_001836.2
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL4A1(1282)
Application
Collagen Type IV from human cell culture has been used in immunofluorescent analysis.
Biochem/physiol Actions
COL4A1 (collagen type IV α 1 chain) related disorder is associated with pulmonary complication. Mutations in COL4A1 result in familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD) and hemorrhagic stroke.
The antibody detects endogenous levels of total Collagen IV protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
COL4A1 (collagen type IV α 1 chain) belongs to the collagen family. It has an N-terminal 7S domain, a C-terminal globular domain (NC1), and the central triple helical part with short interruptions of the Gly-X-Y repeats. It is an important constituent of type IV collagen in the basement membrane. The COL4A1 gene is located on human chromosome 13q34.
Immunogen
Synthesized peptide derived from human Collagen IV.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Sakurai Y, et al.
Molecular Therapy, 24(12), 2090-2099 (2016)
Collagens?structure, function, and biosynthesis
Gelse K, et al.
Advanced Drug Delivery Reviews, 55 (2003)
Association of COL4A1 gene polymorphisms with cerebral palsy in a Chinese Han population.
Bi D, et al.
Clinical Genetics, 90(2), 149-155 (2016)
Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome.
Alamowitch S, et al.
Neurology, 73(22), 1873-1882 (2009)
Yu Sakurai et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(12), 2090-2099 (2016-09-17)
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