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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~93 kDa
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(R-E-E-I-E)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Postn(50706)
一般描述
Periostin (POSTN) gene with 23 exons spanning 36 kb is mapped to chromosome 13q13.3. The gene codes for periostin, a matricellular protein that belongs to the family of non-structural matrix proteins. Periostin structure contains a signal peptide, four fasciclin-like domains (FAS1) with vitamin K-dependent γ-carboxyglutamic acid (Gla) residues, and hydrophilic C-terminal region with the heparin-binding site. The protein is mainly expressed in the periosteum, periodontal ligament, heart valves, and tendons. The antibody detects endogenous level of total periostin protein.
免疫原
Peptide sequence around aa. 125-129 ( R-E-E-I-E), according to the protein NP_006466.2
应用
Anti-POSTN antibody produced in rabbit has been used in western blot.
生化/生理作用
Periostin (POSTN) facilitates extracellular matrix structure and organization. It acts as a collagen chaperone and regulates type I collagen fibrillogenesis. POSTN is implicated in early stages of bone formation, tissue repair, and cell recruitment and adhesion. This protein is essential for cancer stem cell maintenance and metastasis. Increased expression of POSTN has been observed in various types of cancers including prostate, breast, lung, pancreatic, ovarian, and colorectal cancer. Hence, the postn levels can be used as a prognostic biomarker for these cancers.
特点和优势
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目标描述
Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.
Li, et al.
BioMed Research International, 2020, 9405909-9405909 (2020)
Ilaria Malanchi et al.
Nature, 481(7379), 85-89 (2011-12-14)
Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successful initiation
Nicolas Bonnet et al.
The Journal of biological chemistry, 284(51), 35939-35950 (2009-10-20)
Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment and adhesion and plays an important role in odontogenesis. In bone, periostin is preferentially expressed in the periosteum, but its functional significance remains unclear. We investigated Postn(-/-)
Laura González-González et al.
Frontiers in oncology, 8, 225-225 (2018-06-28)
Tumor microenvironment is considered nowadays as one of the main players in cancer development and progression. Tumor microenvironment is highly complex and consists of non-tumor cells (i.e., cancer-associated fibroblast, endothelial cells, or infiltrating leukocytes) and a large list of extracellular
Collagen structure, folding and function
A Text Book of Fibre Science and Technology, 71-84 (2014)
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