推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
65-80 kDa
种属反应性
human
浓度
1 mg/mL
技术
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(R-I-N-R-V)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ABCG2(9429)
一般描述
The ABCG2 (ATP binding cassette subfamily G member 2) gene encodes an ATP-binding cassette (ABC) transporter that is also called as breast cancer resistance protein (BRCP). It is composed of 655 amino-acids and is located on human chromosome 4q22. It belongs to the ABCG (white) subfamily.
The antibody detects endogenous level of total ABCG2(CD338) protein.
The antibody detects endogenous level of total ABCG2(CD338) protein.
免疫原
Peptide sequence around aa. 160-164 ( R-I-N-R-V), according to the protein NP_004818.2
生化/生理作用
ABCG2 (ATP binding cassette subfamily G member 2) serves as a shield for several tissues against xenobiotic molecules. It can provide multidrug resistance (MDR) in breast and other cell lines.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
Doyle L and Ross DD
Oncogene (2003)
Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay
Prasanphanich AF, et al.
PLoS Computational Biology (2016)
Structure of the human multidrug transporter ABCG2
Taylor NMI, et al.
Nature (2017)
Gayathri Heenatigala Palliyage et al.
Lung cancer (Amsterdam, Netherlands), 181, 107258-107258 (2023-05-29)
A cure for cancer is out of reach for most patients due to chemoresistance. Cancer-associated fibroblasts (CAFs) play a vital role in cancer chemoresistance, but detailed understanding of the process particularly in chemoresistant lung cancer is lacking. In this study
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