SAB4300613
Anti-Cry1 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-AU020726 antibody produced in rabbit, Anti-AU021000 antibody produced in rabbit, Anti-Phll1 antibody produced in rabbit, Anti-cryptochrome 1 (photolyase-like) antibody produced in rabbit
产品名称
Anti-Cry1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~60 kDa
species reactivity
mouse
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(S-Q-G-S-G)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Cry1(12952)
Biochem/physiol Actions
Cry1 (cryptochrome circadian regulator 1) controls gluconeogenesis. It induces tumor development and multiplication. Overexpression of Cry1 results in tumor progression and poor clinical indications in individuals with colorectal Cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
Cry1 (cryptochrome circadian regulator 1) belongs to the cryptochrome family. It is located on human chromosome 12q23.
Immunogen
Peptide sequence around aa. 551-555 (S-Q-G-S-G), according to the protein Cry1.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer
Yu H, et al.
PLoS ONE (2013)
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder
Soria V, et al.
Neuropsychopharmacology, 35(6), 1279-1289 (2010)
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American
Dashti HS, et al.
Chronobiology International, 31(5), 660-667 (2014)
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