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安全信息

SAB4300613

Sigma-Aldrich

Anti-Cry1 antibody produced in rabbit

affinity isolated antibody

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别名:
Anti-AU020726 antibody produced in rabbit, Anti-AU021000 antibody produced in rabbit, Anti-Phll1 antibody produced in rabbit, Anti-cryptochrome 1 (photolyase-like) antibody produced in rabbit
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

~60 kDa

种属反应性

mouse

浓度

1 mg/mL

技术

western blot: 1:500-1:1000

同位素/亚型

IgG

免疫原序列

(S-Q-G-S-G)

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

mouse ... Cry1(12952)

一般描述

Cry1 (cryptochrome circadian regulator 1) belongs to the cryptochrome family. It is located on human chromosome 12q23.

免疫原

Peptide sequence around aa. 551-555 (S-Q-G-S-G), according to the protein Cry1.

生化/生理作用

Cry1 (cryptochrome circadian regulator 1) controls gluconeogenesis. It induces tumor development and multiplication. Overexpression of Cry1 results in tumor progression and poor clinical indications in individuals with colorectal Cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder
Soria V, et al.
Neuropsychopharmacology, 35(6), 1279-1289 (2010)
Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer
Yu H, et al.
PLoS ONE (2013)
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American
Dashti HS, et al.
Chronobiology International, 31(5), 660-667 (2014)

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