SAB4300606
Anti-LYVE1 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CRSBP-1 antibody produced in rabbit, Anti-HAR antibody produced in rabbit, Anti-LYVE-1 antibody produced in rabbit, Anti-XLKD1 antibody produced in rabbit, Anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody produced in rabbit
产品名称
Anti-LYVE1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~40 kDa
species reactivity
mouse, human, rat
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(K-N-Q-Q-K)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LYVE1(10894)
Biochem/physiol Actions
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) plays an important role in hyaluronan homeostasis. It controls cellular trafficking of the lymph nodes. It serves as an important lymphatic vessel marker.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) induces activation of its ligand, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF)-A and hyaluronic acid, opens lymphatic intercellular junctions in vitro and in vivo by enhancing contraction of lymphatic endothelial cells (LECs). The encoded protein also facilitates uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) is a type I integral membrane polypeptide. It is present on lymph vessel endothelial cells of both normal and neoplastic tissues. LYVE consists of a single N-terminal HA binding domain. It is mapped to human chromosome 11p15.
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as CRSBP, is encoded by the gene localized on human chromosome 11p15.4. The encoded protein is mainly mapped to the plasma membrane as well as intracellular fibrillar structures in lymphatic endothelial cells (LECs), including primary human dermal LECs and SVEC4-10 cells. LYVE1 belongs to the link module superfamily of C-type lectins.
Immunogen
Peptide sequence around aa. 271-275 (K-N-Q-Q-K), according to the protein LYVE1.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
Bono P, et al.
Clinical Cancer Research, 10(21), 7144-7149 (2004)
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
Banerji S, et al.
The Journal of Cell Biology, 144(4), 789-801 (1999)
Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium
Banerji S, et al.
The Journal of Biological Chemistry, 291(48), 25004-25018 (2016)
Identification of a three-gene expression signature of poor-prognosis breast carcinoma
Bieche I, et al.
Molecular Cancer, 3(1), 37-37 (2004)
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