SAB4300592
Anti-PXN (Ab-88) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-FLJ16691 antibody produced in rabbit, Anti-paxillin antibody produced in rabbit
产品名称
Anti-PXN (Ab-88) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~68 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:50-1:100
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(P-V-Y-G-S)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PXN(5829)
Application
Anti-PXN (Ab-88) antibody has been used in immunofluorescence.
Biochem/physiol Actions
Paxillin (PXN) controls signal transduction, cell morphology and motility, cytoskeletal rearrangements, proliferation and apoptosis. It serves as an oncogene, hence it plays a major role in the growth of human carcinomas.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
PXN (paxillin) is a focal adhesion-associated tyrosine-based protein, that is present in the cytoplasm. It is a 68kDa protein that is located on chromosome 12q24.
Immunogen
Peptide sequence around aa. 86-90 (P-V-Y-G-S), according to the protein PXN.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells
Du C, et al.
Oncology Reports, 35(1), 409-417 (2016)
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
Carlisle FA, et al.
Gene Expression Patterns, 12(5-6), 172-179 (2012)
Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients
Zhao CJ, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 1989-1995 (2015)
Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value
Li L, et al.
International Journal of Clinical and Experimental Pathology, 8(8), 9232-9239 (2015)
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells
Maier B, et al.
Cell Cycle, 12(9), 1457-1471 (2013)
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