SAB4300564
Anti-SMAD3 (Ab-208) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp586N0721 antibody produced in rabbit, Anti-DKFZp686J10186 antibody produced in rabbit, Anti-HSPC193 antibody produced in rabbit, Anti-HsT17436 antibody produced in rabbit, Anti-SMAD family member 3 antibody produced in rabbit
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所有图片(2)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~52 kDa
种属反应性
rat, human, mouse
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
同位素/亚型
IgG
免疫原序列
(N-L-S-P-N)
NCBI登记号
UniProt登记号
应用
research pathology
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SMAD3(4088)
一般描述
SMAD3 (SMAD family member 3) is located on chromosome 15q22.
免疫原
Peptide sequence around aa. 206-210 (N-L-S-P-N), according to the protein SMAD3.
生化/生理作用
SMAD3 (SMAD family member 3) plays a major role in the intracellular signaling of transforming growth factorβ(TGFβ). Reducing the phosphorylation level of Smad3 helps autophagy to control endothelial-mesenchymal transition. In arterial smooth muscle cells, suppression of SMAD3 results in elevating cell viability.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
Turner AW, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(5), 972-983 (2016)
Genetic risk factors for the development of allergic disease identified by genome-wide association
Portelli MA, et al.
Clinical and Experimental Allergy, 45(1), 21-31 (2015)
Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3
Wang J, et al.
Biochemical and Biophysical Research Communications, 487(3), 740-747 (2017)
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
Dennler S, et al.
The Embo Journal, 17(11), 3091-3100 (1998)
Lingfang Zeng et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(10), 2134-2144 (2015-09-01)
Smooth muscle cell (SMC) migration and proliferation play an essential role in neointimal formation after vascular injury. In this study, we intended to investigate whether the X-box-binding protein 1 (XBP1) was involved in these processes. In vivo studies on femoral
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