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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~43 kDa
种属反应性
rat, human, mouse
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(Q-A-S-F-R)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GAP43(2596)
一般描述
Growth associated protein-43 (GAP-43) is a phosphoprotein associated with membrane. It is located on chromosome 3q13. During neural development and axonal regeneration, GAP43 is upregulated in neuronal growth cones and Schwann cell precursors.
免疫原
Peptide sequence around aa. 38-43 (Q-A-S-F-R), according to the protein GAP43.
生化/生理作用
Growth associated protein-43 (GAP-43) participates in neurite outgrowth, growth cone navigation, neurotransmission, stabilization of axonal branches and synaptic plasticity. In humans and mice, GAP43 is recognized as a possible gene for autism and autistic-like disorders.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Víctor Carriel et al.
Journal of tissue engineering and regenerative medicine, 11(2), 553-563 (2014-08-02)
Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used
A rare 3q13.31 microdeletion including GAP43 and LSAMP genes
Gimelli S, et al.
Molecular Cytogenetics, 6(1), 52-52 (2013)
Ryan L O'Hare Doig et al.
Frontiers in molecular neuroscience, 13, 85-85 (2020-07-17)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+
Jesús Chato-Astrain et al.
Frontiers in cellular neuroscience, 12, 501-501 (2019-01-11)
The regenerative capability of peripheral nerves is very limited, and several strategies have been proposed to increase nerve regeneration. In the present work, we have analyzed the in vivo usefulness of a novel nanostructured fibrin-agarose bio-artificial nerve substitute (Nano) used
Jesús Chato-Astrain et al.
Neural regeneration research, 18(8), 1852-1856 (2023-02-09)
Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton remodeling. We have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone formation. Conversely, the limited regenerative capacity of the
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