SAB4300523
Anti-EIF2S1 (Ab-51) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-EIF-2 antibody produced in rabbit, Anti-EIF-2A antibody produced in rabbit, Anti-EIF-2alpha antibody produced in rabbit, Anti-EIF2 antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa antibody produced in rabbit
产品名称
Anti-EIF2S1 (Ab-51) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~38 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(E-L-S-R-R)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EIF2S1(1965)
Biochem/physiol Actions
EIF2S1 (eukaryotic translation initiation factor 2 subunit α) serves as an important enzyme in protein elongation during translation. EIF2S1 catalyses the translocation of peptidyl-tRNA from A site to P site in the ribosome. Phosphorylation by EF2 kinase, inactivates EIF2S1 followed by inhibition of protein synthesis. Upregulation of EIF2S1 gene is observed in malignant tumors, such as gastrointestinal cancer, lung adenocarcinoma, ovary cancer, soft-tissue sarcomas and hepatocellular carcinoma. The GTP-bound eIF2S1 protein is regarded as the active form and recruits initiator methionyl tRNA to 40S ribosomal subunit, one of the key step in translation initiation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
The eukaryotic translation initiation factor 2 subunit α (EIF2S1) gene codes for a heterotrimeric GTPase which is localized to the cytoplasm. The EIF2S1 gene is mapped to human chromosome 14q23.3.
Immunogen
Peptide sequence around aa. 49-53 (E-L-S-R-R), according to the protein EIF2S1.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Song Y, et al.
Oncotarget, 7(36), 58470-58470 (2016)
Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.
Bogorad A M, et al.
Nucleic Acids Research, 45(20), 11962-11979 (2017)
PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly.
Ilan L, et al.
Cell Research, 27(5), 688-688 (2017)
Identification of carboxypeptidase E and γ-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.
He P, et al.
Human Pathology, 35(10), 1196-1209 (2004)
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