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安全信息

SAB4300492

Sigma-Aldrich

Anti-CDC2 (Ab-15) antibody produced in rabbit

affinity isolated antibody

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别名:
Anti-CDC28A antibody produced in rabbit, Anti-CDK1 antibody produced in rabbit, Anti-DKFZp686L20222 antibody produced in rabbit, Anti-MGC111195 antibody produced in rabbit, Anti-cell division cycle 2, G1 to S and G2 to M antibody produced in rabbit
MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

~34 kDa

种属反应性

human, rat, mouse

浓度

1 mg/mL

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

同位素/亚型

IgG

免疫原序列

(G-T-Y-G-V)

NCBI登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CDC2(983)

一般描述

CDC2/CDK1 (cyclin-dependent kinase 1) belongs to the Ser/Thr protein kinase family. It is located on human chromosome 10q21.

免疫原

Peptide sequence around aa. 13-17 (G-T-Y-G-V), according to the protein CDC2.

生化/生理作用

CDC2/CDK1 (cyclin-dependent kinase 1) controls various mitotic processes like reorganization of the cytoskeleton, segregation of chromosome, formation and separation of daughter cells. It is essential for the multiplication of mammalian cell. It participates in tumorigenesis.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
Bieche I, et al.
Molecular Cancer, 10:23 (2011)
Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma
Bednarek K, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(8), 11115-11126 (2016)
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics
Petrone A, et al.
Molecular and Cellular Proteomics, 15(7), 2448-2461 (2016)

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