SAB4300461
Anti-RAC1 (Ab-71) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-MGC111543 antibody produced in rabbit, Anti-MIG5 antibody produced in rabbit, Anti-TC-25 antibody produced in rabbit, Anti-p21-Rac1 antibody produced in rabbit, Anti-ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody produced in rabbit
产品名称
Anti-RAC1 (Ab-71) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~28 kDa
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(P-L-S-Y-P)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAC1(5879)
Application
Anti-RAC1 (Ab-71) antibody has been used in western blot analysis .
Biochem/physiol Actions
RAC1 (ras-related C3 botulinum toxin substrate 1) plays a major role in cancer invasion and metastasis. It can be considered as a therapeutic target for breast cancer. It is essential for several cellular activities like phagocytosis, adhesion, migration, motility, cell proliferation and axonal growth.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
RAC1 (ras-related C3 botulinum toxin substrate 1) is a polarity related protein , that belongs to the Rho family of small guanosine triphosphatases. It is located on human chromosome 7p22.
Rac1 encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen
Peptide sequence around aa. 69-73 (P-L-S-Y-P), according to the protein RAC1.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Case of 7p22.1 Microduplication Detected by Whole Genome Microarray (REVEAL) in Workup of Child Diagnosed with Autism
Goitia V, et al.
Case Reports in Genetics (2015)
Emerging roles of RAC1 in treating lung cancer patients
Zou T, et al.
Clinical Genetics, 91(4), 520-528 (2017)
High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast
Liu B, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(7) (2017)
Estradiol attenuates the TGF-?1-induced conversion of primary TAFs into myofibroblasts and inhibits collagen production and myofibroblast contraction by modulating the Smad and Rho/ROCK signaling pathways
Jiang HS, et al.
International Journal of Molecular Medicine, 36(3), 801-807 (2015)
Caixia Yuan et al.
Experimental and therapeutic medicine, 17(4), 2547-2556 (2019-03-25)
Bone morphogenetic protein (BMP) expression has been observed in the uterus in previous studies. However, the influence of BMP7 on blastocyst implantation remains unclear. Blastocysts first act on luminal endometrial epithelial cells during implantation. The purpose of the present study
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