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安全信息

SAB4300396

Sigma-Aldrich

Anti-CHUK (Ab-23) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-IKBKA antibody produced in rabbit, Anti-IKK-alpha antibody produced in rabbit, Anti-IKK1 antibody produced in rabbit, Anti-IKKA antibody produced in rabbit, Anti-conserved helix-loop-helix ubiquitous kinase antibody produced in rabbit

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

~85 kDa

种属反应性

rat, human, mouse

浓度

1 mg/mL

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

同位素/亚型

IgG

免疫原序列

(L-G-T-G-G)

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CHUK(1147)

相关类别

免疫原

Peptide sequence around aa. 21-25 (L-G-T-G-G), according to the protein CHUK.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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