产品名称
抗-磷酸化-FOXO1 (pSer256) 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
78-82 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(A-A-SP-M-D)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer256)
Quality Level
Gene Information
human ... FOXO1(2308)
Application
兔抗磷酸化-FOXO1 (pSer256)抗体可用于蛋白质印迹。
Biochem/physiol Actions
FOXO1（叉头盒O1）可阻断胎儿胰腺祖细胞中细胞的分化。它控制脂肪细胞的分化。FOXO1参与葡萄糖-6-磷酸酶（G6p）表达的胰岛素调节。此外，该蛋白通过诱导生长停滞和凋亡在肿瘤抑制中起着至关重要的作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
FOXO1（叉头盒O1）是由定位于人类染色体13q14的基因编码的。编码的蛋白质是转录因子，是Foxo亚家族的成员。
转录因子。
Immunogen
基于蛋白质FOXO1的丝氨酸256 (A-A-S(p)-M-D)磷酸化位点周围的肽序列。
Physical form
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲液
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Limin Shi et al.
Methods in molecular biology (Clifton, N.J.), 2594, 97-106 (2022-10-21)
The transcription factor FoxO1 (forkhead box O1) regulates genes that are involved in development, metabolism, cellular innovation, longevity, and stress responses. Assessment of FoxO1 activity is therefore critical to understand the regulatory network of this transcription factor. FoxO1 transactivation activity
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
Nakae J
The Journal of Clinical Investigation, 108, 1359-1367 (2001)
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
Huang H
Proceedings of the National Academy of Sciences of the USA, 102, 1649-1654 (2005)
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic ? cell growth
Nakae J
The Journal of Clinical Investigation, 110, 1839?1847-1839?1847 (2002)
The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation
Nakae J
Developmental Cell, 4, 119-129 (2003)
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