SAB4300069
Anti-phospho-IGF1R (pTyr1165/pTyr1166) antibody produced in rabbit
affinity isolated antibody
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别名:
Anti-CD221 antibody produced in rabbit, Anti-IGFIR antibody produced in rabbit, Anti-JTK13 antibody produced in rabbit, Anti-MGC142170 antibody produced in rabbit, Anti-insulin-like growth factor 1 receptor antibody produced in rabbit
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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~200 kDa
~95 kDa
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(T-D-YP-YP-R-K)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr1165/pTyr1166)
基因信息
human ... IGF1R(3480)
一般描述
Insulin like growth factor 1 receptor (IGF1R) is encoded by the gene mapped to human chromosome 15q25- qter. The encoded protein is a transmembrane heterotetramer. It is structurally similar to insulin receptor.
免疫原
Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K), according to the protein IGF1R.
生化/生理作用
Insulin like growth factor 1 receptor (IGF1R) on binding to its ligand, IGF2 regulates cell proliferation and growth. The encoded protein is also facilitates the normal embryonic and postnatal growth. It plays a crucial role in the embryonic growth. Mutations in IGF2 are associated with Silver–Russell syndrome and ring chromosome 15 syndrome. It is upregulated in ovarian cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Paternally Inherited IGF2 Mutation and Growth Restriction.
Begemann M
The New England Journal of Medicine, 373, 349-356 (2015)
Hemizygosity at the insulin-like growth factor I receptor (IGF1R) locus and growth failure in the ring chromosome 15 syndrome.
Peoples R
Cytogenetics and Cell Genetics, 70, 228-234 (1995)
High IGF2 expression is associated with poor clinical outcome in human ovarian cancer.
Dong Y
Oncology Reports, 34 (2015)
Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.
Okubo Y
The Journal of Clinical Endocrinology and Metabolism, 88, 5981-5988 (2003)
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