生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~88 kDa
种属反应性
mouse, human, rat
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(P-M-SP-P-R)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer727)
基因信息
human ... STAT3(6774)
一般描述
信号传感器和转录激活因子3 (STAT3)是白介素-6- (IL-6)激活的急性期反应因子(APRF)复合物的组成部分，属于信号传感器和转录激活因子(STAT)家族。在所有类型的组织中都有表达。STAT3基因有24个外显子，定位于人类染色体17q21.2。
免疫原
基于蛋白质STAT3的丝氨酸727（PMS（p）-PR）磷酸化位点周围的肽序列。
应用
兔产生的抗磷酸化stat3 (pSer727)抗体已被用于免疫印迹(1:1000)和免疫荧光染色(1:20 00)。
生化/生理作用
信号传感器和转录激活因子3 (STAT3)蛋白在细胞生长、凋亡、代谢、细胞呼吸和自噬中起关键作用。它可能是糖皮质激素受体信号转导的共激活物。STAT3可调节转录。它参与脊椎动物的发育以及炎症和免疫的调节。可能参与气道炎症、过敏和哮喘。STAT3基因突变与免疫缺陷、自身免疫和癌症相关。
特点和优势
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
目标描述
能与多种急性期蛋白基因启动子中所鉴定的白介素6（IL-6）反应元件结合的转录因子。其可由IL31通过IL31RA进行激活。
外形
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Not finding the right product?
Try our 产品选型工具.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Emily J Hillmer et al.
Cytokine & growth factor reviews, 31, 1-15 (2016-05-18)
The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of
Fabian Gärtner et al.
Frontiers in immunology, 12, 745132-745132 (2021-12-07)
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass
Rossana Cocchiola et al.
International journal of molecular sciences, 20(8) (2019-04-25)
STAT3 is an oncoprotein overexpressed in different types of tumors, including prostate cancer (PCa), and its activity is modulated by a variety of post-translational modifications (PTMs). Prostate cancer represents the most common cancer diagnosed in men, and each phase of
Akanksha Khandelwal et al.
Cancer science, 111(3), 826-839 (2019-09-15)
Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. In this context, use of circulating microRNAs (miRNAs) may serve
Kayvan Saeedfar et al.
Tanaffos, 16(1), 1-8 (2017-06-24)
Despite being a high burden disorder, the pathogenesis of severe refractory asthma (SRA) is poorly understood. There are some evidences for the involvement of members of the signal transducer and activator of transcription (STAT) family, including STAT3 and STAT5a. Our
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门