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Merck
CN

SAB4200476

Anti-ALIX antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-AIP1, Anti-ALG-2 interacting protein 1, Anti-DRIP4, Anti-HP95, Anti-PDCD6IP, Anti-apoptosis-linked gene 2-interacting protein X, Anti-dopamine receptor interacting protein 4, Anti-programmed cell death 6 interacting protein

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

主要文件

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产品名称

Anti-ALIX antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~95 kDa

species reactivity

mouse, human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of human Jurkat cells.
western blot: 2.5-5 μg/mL using whole extracts of mouse A20 cells.

UniProt accession no.

Q8WUM4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PDCD6IP(10015)
mouse ... Pdcd6ip(18571)

Application

Anti-ALIX antibody produced in rabbit has been used in immunoprecipitation and immunoblotting.

Biochem/physiol Actions

ALIX (Apoptosis-linked gene 2 (ALG-2)-interacting protein X binds to endophilins, proteins that regulate membrane shape during endocytosis. Over-expression of ALIX and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death.
PDCD6IP (programmed cell death 6 interacting protein) interacts with PDCD6, a protein involved in apoptosis. It also participates in intraluminal endosomal vesicle biogenesis, viral budding and cytokinetic abscission. PDCD6IP is a part of the ESCRT (endosomal sorting complexes required for transport) machinery.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The gene PDCD6IP (programmed cell death 6 interacting protein), also known as ALIX (apoptosis-linked gene 2-interacting protein X), is mapped to human chromosome 3p22.1 The protein has a crescent-shaped Bro1 domain, V-shaped V domain and a proline-rich region.

Immunogen

peptide corresponding to an internal region of human ALIX/ PDCD6IP, conjugated to KLH. The corresponding sequence is identical in monkey, bovine and dog and differs by 2 amino acids in mouse and rat.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000212106
0000201414
0000212106
072M4769V
059M4854V

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Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population.
Hashemi M
Disease Markers (2015)
ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly.
Ku PI
PLoS ONE, 9 (2014)
Heparanase activates the syndecan-syntenin-ALIX exosome pathway.
Roucourt B
Cell Research, 25, 412-428 (2015)
James J Vanhie et al.
Frontiers in physiology, 13, 1054463-1054463 (2022-12-13)
Exercise and obesity regulate hematopoiesis, in part through alterations in cellular and soluble components of the bone marrow niche. Extracellular vesicles (EVs) are components of the bone marrow niche that regulate hematopoiesis; however, the role of exercise training or obesity
Lalithasri Ramasubramanian et al.
ACS applied materials & interfaces, 14(49), 54458-54477 (2022-12-01)
Lipid rafts are highly ordered regions of the plasma membrane enriched in signaling proteins and lipids. Their biological potential is realized in exosomes, a subclass of extracellular vesicles (EVs) that originate from the lipid raft domains. Previous studies have shown
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