Anti-Lamin A, mature antibody, Mouse monoclonal

Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.

synthetic peptide corresponding to the C-terminus of mature human Lamin A.

Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.

Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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