SAB3701431
Monoclonal Anti-Esrp-1/2 antibody produced in mouse
clone 23A7.C9, purified immunoglobulin
别名:
Anti-Epithelial splicing regulatory protein 1, Anti-RNA-binding motif protein 35A, Anti-RNA-binding protein 35A, Anti-RNA-binding protein 35B, Anti-Rbm35a
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所有图片(1)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
23A7.C9, monoclonal
表单
buffered aqueous solution
种属反应性
mouse
技术
ELISA: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Esrp2(77411)
一般描述
Epithelial splicing regulatory protein 1 (ESRP1) is a member of RBM family of RNA-binding proteins. It is also known as RBM35A. ESRP1 get highly expressed in both mouse and human epithelial stem cells and weakly expressed in normal pancreatic ductal cells.
特异性
This antibody was purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with both mouse Esrp-1 and Esrp-2 proteins. A BLAST analysis of the immunizing protein sequence shows 100% homology with Esrp-1 from mouse and a 91% sequence homology with Esrp-1 from human, pig, rat, opossum, horse, cattle, panda, dog, and chimpanzee . The binding epitope of this monoclonal antibody has not been mapped
免疫原
Full length recombinant mouse Esrp-1 fusion protein.
生化/生理作用
Epithelial splicing regulatory protein 1 (ESRP1) is essential for the expression of epithelial FGFR2-IIIb (fibroblast growth factor receptor 2). Suppression of ESRP1 can enhance induced pluripotent stem (iPS) cell colony generation. It can also repress cancer cell motility by different mechanisms. ESRP1 modulates splicing of Ras-related C3 botulinum toxin substrate 1 (Rac1) isoforms and participates in the maintenance of epithelial cell-specific isoforms. The protein controls epithelial splicing regulatory network and pluripotency.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.
Ishii H, et al.
The Journal of Biological Chemistry, 289(40), 27386-27399 (2014)
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.
Warzecha C C, et al.
RNA Biology, 6(5), 546-562 (2009)
The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.
Fagoonee S, et al.
PLoS ONE, 8(8), e72300-e72300 (2013)
Claude C Warzecha et al.
Molecular cell, 33(5), 591-601 (2009-03-17)
Cell-type-specific expression of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved through tight regulation of mutually exclusive exons IIIb and IIIc, respectively. Using an application of cell-based cDNA expression screening, we identified two paralogous epithelial
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