推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 24 kDa
种属反应性
human
浓度
1 mg/mL
技术
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IL37(27178)
一般描述
IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.
免疫原
Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
生化/生理作用
IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4+CD25+ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500952.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Interleukin-1 as a Key Factor in the Development of Inflammatory Diseases.
Farivar S, et al.
Archives of Pediatric Infectious Diseases, 2(4), e18177-e18177 (2014)
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis.
Lin XY, et al.
Medicine, 97(15), e0386-e0386 (2018)
The interleukin-1 family: back to the future.
Garlanda C, et al.
Immunity, 39(6), 1003-1018 (2013)
Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease.
Yan N, et al.
Journal of Molecular Endocrinology, 55(3), 209-218 (2015)
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
McCurdy S, et al.
Journal of Immunology, 199(10), 3604-3613 (2017)
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