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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
rat, mouse, human
技术
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NLRC3(197358)
一般描述
NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.
免疫原
NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.
生化/生理作用
NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500544.
外形
Supplied in PBS with 0.02% sodium azide.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
Zhang L, et al.
Immunity, 40(3), 329-341 (2014)
Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
Liu R, et al.
Oncotarget, 6(32), 33456-33456 (2015)
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases
Wilmanski, et al.
Journal of Leukocyte Biology, 83(1), 13-30 (2008)
NLRC3 is an inhibitory sensor of PI3K?mTOR pathways in cancer
Karki R, et al.
Nature, 540(7634), 583-583 (2016)
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