推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 66 kDa
种属反应性
rat, mouse, human
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IRAK3(11213)
一般描述
The IRAKM (interleukin-1 receptor-associated kinase-3) gene is mapped to human chromosome 12q14.3. This gene is predominantly expressed in monocytes and macrophages.
免疫原
IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M .
应用
Anti-IRAK-M antibody produced in rabbit has been used in Western blotting, immunoprecipitation and immunofluorescence.
生化/生理作用
The Irakm (interleukin-1 receptor-associated kinase-3) protein downregulates the toll like receptor (TLR)-signalling and influences the action of nuclear factor-κB (NF-κB). Increased IRAKM expression is observed in inflammatory bowel disease (IBD) and colorectal cancer. It is known to reduce the immune response against microorganism.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500193.
外形
Supplied in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
相关产品
储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury
Pino Yanes M, et al.
American Journal of Respiratory Cell and Molecular Biology, 45(4), 740-745 (2011)
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
Nechama M, et al.
Nature Communications, 9(1), 1603-1603 (2018)
Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
Sode J, et al.
Pharmacogenomics, 18(1), 81-81 (2018)
Enhanced mucosal defense and reduced tumor burden in mice with the compromised negative regulator IRAK-M
Rothschild DE, et al.
EBioMedicine, 15(1), 36-47 (2017)
Implication of the toll-like receptor 4 pathway in the response to interferon-beta in multiple sclerosis
Bustamante MF, et al.
Annals of Neurology, 70(4), 634-645 (2011)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门