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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
rat, human, mouse
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RSPO1(284654)
一般描述
R-spondin 1 (RSPO1) is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular β-catenin, thereby regulating functions mediated by β-catenin such as cell fate decisions and embryonic patterning. It possesses two furin-like cysteine-rich domains at the amino-terminus, a thrombospondin domain and a carboxy-terminal tail. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members. The gene encoding RSPO1 is localized on human chromosome 1p34.3.
免疫原
RSPO1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human RSPO1.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry-frozen tissue (1 paper)
Immunohistochemistry-frozen tissue (1 paper)
生化/生理作用
RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500046.
外形
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
Proceedings of the National Academy of Sciences of the USA (2007)
R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism
Molecular Biology of the Cell (2008)
Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development
BMC Developmental Biology (2008)
WNT4 and RSPO1 Are Not Involved in a Case of Male-to-Female Sex Reversal with Partial D
Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation (2007)
Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.
PloS one, 9(12), e114433-e114433 (2014-12-11)
Wnt signaling regulates self-renewal and fate commitment of stem and progenitor cells in development and homeostasis. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is a co-receptor for Wnt signaling that marks highly proliferative stem and progenitor cells in many epithelial
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