Anti-FNIP2 antibody produced in rabbit

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O⁶-methylguanine-induced apoptosis signaling pathway.

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FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

The action of this antibody can be blocked using blocking peptide SBP3500010.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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