Anti-ADCYAP1R1 antibody produced in rabbit

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein is a member of the class B G-protein-coupled receptors (GPCRs). It is expressed ubiquitously in the central nervous system (CNS) and peripheral tissues. It has an N-terminal extracellular domain (ECD) and a transmembrane domain (TMD). ADCYAP1R1 gene is located on human chromosome 7p14.

Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Bat, Chicken, Lizard, Xenopus (100%); Stickleback, Pufferfish, Zebrafish (94%); Mouse, Rat, Hamster, Elephant, Bovine, Horse, Pig (88%).

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein can activate the adenylyl cyclase stimulatory G protein Gs. It regulates circadian rhythm, food intake, and the immune system. PAC1R plays a vital role in glucose metabolism, learning and memory, neuronal ontogenesis, and apoptosis. ADCYAP1R1 is identified as a potential drug target for mental disorders and dry eye syndrome.

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Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

Supplied at 1 mg/ml

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